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Drug Information
Nesina (Alogliptin) is a once-daily oral medication prescribed for adults with type 2 diabetes. As a DPP-4 inhibitor, it is used alongside a proper diet and exercise plan to improve glycemic control. It can be used alone or as part of combination therapy with other diabetes medications to help lower blood sugar levels safely.
Quick Facts Table
| Attribute | Details |
| Drug Name | Nesina (Alogliptin) |
| Drug Class | DPP-4 inhibitor |
| Primary Indications | Type 2 diabetes mellitus |
| Prescription Required | Yes |
| Typical Dose | 25 mg once daily (adjustments for renal impairment) |
| Renal Dosing | Adjustments required for moderate to severe impairment |
| Pregnancy Considerations | Consult clinician; safety category not established |
| Administration | Oral tablet with or without food |
| Monitoring | Lab monitoring for kidney function, pancreatic enzymes and glycemic control |
| Shipping Region | United States |
What is Nesina?
Nesina, with the active ingredient Alogliptin, is a prescription medicine used to manage blood sugar in adults with type 2 diabetes mellitus. It helps the body produce more insulin just after a meal when blood glucose is highest.
Mechanism of Action
Nesina (Alogliptin) is one of the DPP-4 inhibitors. It works by blocking the dipeptidyl peptidase-4 (DPP-4) enzyme, which increases the levels of natural substances called incretins (GLP-1, GIP). Incretins help to control blood sugar levels by increasing insulin release and decreasing the amount of sugar made by the liver.
Indications and Use
Nesina (Alogliptin) is approved to improve glycemic control in adults with type 2 diabetes. It is used in conjunction with diet and exercise and can be prescribed as a monotherapy or with other diabetes medications like metformin or insulin.
Dosing and Administration
It is essential to follow your healthcare professional’s instructions and the information in the medication guide when taking Nesina.
Standard Dosage
The typical dose of Nesina (Alogliptin) is 25 mg taken once daily.
Renal Dosing
For patients with moderate to severe kidney disease, the Nesina dosage must be adjusted. Lower doses of 12.5 mg or 6.25 mg may be prescribed based on your level of kidney function as determined by blood tests.
Administration Notes
Nesina can be taken as an oral tablet with or without food. Taking it at the same time each day can help you remember to take it and maintain steady levels in your blood.
Missed Dose
If you have a missed dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one. Never take two doses at the same time to make up for a missed one.
Indications and Usage
Nesina (Alogliptin) is used to improve blood sugar control in adults with type 2 diabetes. It is typically part of a comprehensive treatment plan that may include other medicines, a healthy diet and regular physical activity to manage the condition effectively.
Side Effects and Safety
Before taking Nesina, tell your doctor about your medical history and any other drugs you are taking.
Common Side Effects
The most common Nesina side effects include:
- Sore throat and stuffy or runny nose (upper respiratory tract infection or nasopharyngitis)
- Back or joint pain
- Stomach pain or indigestion
- Headache
Serious Risks
Stop taking Nesina (Alogliptin) and call your doctor immediately if you experience serious symptoms. These can include:
- Pancreatitis (inflamed pancreas): Signs include severe stomach pain that may spread to your back, with or without vomiting.
- Heart failure: Watch for symptoms like shortness of breath, rapid weight gain or swelling in your feet or legs.
- Severe allergic reactions: This may include a skin rash, hives, trouble breathing or hive-like swelling of the face, lips, tongue or throat.
- Severe joint pain: Some people taking DPP-4 inhibitors have developed severe and disabling joint pain.
- Liver problems: Symptoms include unusual tiredness, loss of appetite, upper stomach pain, dark urine, or yellowing of the skin or eyes (light-colored stools).
- Serious skin reactions: like Stevens-Johnson syndrome
Safety Considerations
Use Nesina with caution if you have kidney problems. Regular blood sugar testing is necessary to monitor your response. Drinking alcohol can affect your blood sugar level so discuss this with your doctor.
Nesina vs Other DPP-4 Inhibitors
Nesina is one of several DPP-4 inhibitors available. It has a similar efficacy and safety profile to others in its class. The choice between them often depends on patient-specific factors like kidney disease, potential drug interactions and cost.
Nesina with Other Diabetes Meds
Nesina is often used as part of combination therapy. When used with other diabetes medications like metformin, SGLT2 inhibitors or insulin, there is an increased risk of low blood sugar (hypoglycemia). Your doctor may need to adjust the dose of your other medications.
Refill and Online Access
You can get your Nesina refill online through licensed pharmacies with a valid doctor’s prescription. Choose a pharmacy that facilitates a secure process to ensure you receive authentic medication from a trusted source, with verification steps to confirm legitimacy.
Monitoring and Safety Labs
While taking Nesina, your healthcare professional will order periodic blood tests to monitor your kidney problems, liver function, and overall glycemic control. Regular blood sugar regularly monitoring at home is also important.
Prescribing in Special Groups
Nesina pregnancy considerations are important. It is not known if Nesina will harm an unborn baby. It may also pass into breast milk. Consult your clinician if you are pregnant, planning to become pregnant, or breastfeeding. Caution is also advised for elderly patients or those with multiple health issues.
Tablet Strengths and Formulations
Nesina is available in several dosage forms to allow for dose adjustments based on kidney function. The typical Nesina tablet strength is 25 mg. Lower dosages are prescribed based on your level of kidney function.
References and Editorial Review
The information on this page is based on clinical studies and peer-reviewed medical journals. All content is written and reviewed by certified medical experts and is regularly updated to reflect the latest research and guidelines to ensure accuracy.
Legal & Medical Disclaimer
This content is for informational purposes only and should not replace professional medical advice. Nesina (Alogliptin) is a prescription medication that must be used under the supervision of a healthcare professional. Always talk to your doctor before starting or stopping any therapy.
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Frequently Asked Questions
What is Nesina used to treat?
Nesina is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.
What is the standard starting dose for Nesina?
The standard starting dose is 25 mg once daily.
How should Nesina be adjusted for kidney disease?
The dose is lowered to 12.5 mg or 6.25 mg once daily for patients with moderate to severe kidney disease.
What are common and serious side effects?
Common side effects include cold-like symptoms and headache. Serious risks include pancreatitis, heart failure and severe allergic reactions.
Can Nesina be used with metformin, SGLT2 inhibitors or insulin?
Yes, but this increases the risk of low blood sugar. Your doctor may need to adjust the doses of your other medications.
How does Nesina compare to other DPP-4 inhibitors?
It has a similar effectiveness and safety profile. The choice depends on individual patient factors and cost.
What should patients monitor while taking Nesina?
Patients should monitor for signs of pancreatitis, heart failure, allergic reactions and check their blood sugar regularly.
Is Nesina safe during pregnancy or in elderly patients?
The safety of Nesina during pregnancy is not established. It should be used with caution in elderly patients. Consult a doctor for advice.
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